Qinying Zhao+, Xudong Zhao+, Zhiyi Liu+, Yi Ge, Jiaxiong Ruan, Hongyi Cai, Shasha Zhang, Chenliang Ye, Yu Xiong, Wei Chen, Ge Meng, Zhiliang Liu*, Jian Zhang*. Constructing Pd and Cu Crowding Single Atoms by Protein Confinement to Promote Sonogashira Reaction

Release time:2024-09-05 Hits:

DOI number:10.1002/adma.202000896

Journal:Advanced Materials

Key Words:For multicenter‐catalyzed reactions, it is important to accurately construct heterogeneous catalysts containing multiple active centers with high activity and low cost, which is more challenging compared to homogeneous catalysts because of the low activity and spatial confinement of active centers in the loaded state. Herein, a convenient protein confinement strategy is reported to locate Pd and Cu single atoms in crowding state on carbon coated alumina for promoting Sonogashira reaction, the most powerful method for constructing the acetylenic moiety in molecules. The single‐atomic Pd and Cu centers take advantage in not only the maximized atomic utilization for low cost, but also the much‐enhanced performance by facilitating the activation of aryl halides and alkynes. Their locally crowded dispersion brings them closer to each other, which facilitates the transmetallation process of acetylide intermediates between them. Thus, the Sonogashira reaction is drove smoothly by the obtained catalyst with a turnover frequency value of 313 h−1, much more efficiently than that by commercial Pd/C and CuI catalyst, conventional Pd and Cu nanocatalysts, and mixed Pd and Cu single‐atom catalyst. The obtained catalyst also exhibits the outstanding durability in the recycling test.

Indexed by:Journal paper

Discipline:Natural Science

Document Type:J

Volume:2024

Page Number:2402971

Translation or Not:no

Date of Publication:2024-07-16

Included Journals:SCI

Links to published journals:https://onlinelibrary.wiley.com/doi/10.1002/adma.202402971